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With insulin, there is risk of weight gain, for hypoglycemia, and theres more treatment burden and need for glucose monitoring. GLP-1 drugs have also been shown to have cardiovascular benefits, she adds, though further clinical trials are needed to assess orforgliprons effects on heart health

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It has also been proposed as a treatment for several symptoms or complications of dialysis, including intradialytic arrhythmias and hypotension, low cardiac output, interdialytic and post-dialytic symptoms of malaise or asthenia, general weakness or fatigue, skeletal muscle cramps, and decreased exercise capacity or low peak oxygen consumption

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