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Previous observations also highlighted the stimulatory role of IGF-2 in the proliferation [18] and expression of progesterone and estradiol in luteinized granulosa cells in humans [19, 20]

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In addition, the proposed structureactivity relationships are based on a limited set of compounds, making it difficult to establish definitive correlations regarding the influence of arene ligands, curcuminoid backbones, or PTA coordination on biological behaviour

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