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Dermatology Research and Practice , 2012, 135206
Individuals with ARTHS present with developmental delay, cognitive impairment (100% penetrance), delay or absence of speech (100%), facial dysmorphism (85%), feeding difficulties (78%), and neonatal hypotonia (76%) in a study of 76 individuals with KAT6A mutations (Kennedy et al, 2019)
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The decision to adjust dose based on heart rate should involve the overall clinical picture, not just one number in isolation
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