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The combination of large extracellular domains (ECD), extended orthosteric binding sites, and conformational flexibility makes class B1 GPCRs interesting but challenging targets for rational ligand discovery and particularly demanding benchmarks for computational ligand design and virtual screening methodologies (Aksu et al., 2024

The culprit, L-carnitine, is sometimes taken as a nutritional supplement, which may be unwise for meat eaters, the researchers said

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L-Arginine is an amino acid that is a precursor to nitric oxide