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Neonatal icterus with resultant kernicterus that may lead to neurological deficits and mental retardation has the gravest consequences

S., Drobintseva, A

By identifying and treating low brain folate early, significant improvements in cognition, speech, motor function, and neurological health can be achieved

Difluoromethylornithine decreases postischemic brain edema and blood-brain barrier breakdown

Materials and methods Drugs and chemicals Powdered L-PAM and BSO (DL buthionine-( S,R )-sulfoximine) were purchased from Sigma-Aldrich (St Louis, MO, USA) and clinical grade BSO (L-buthionine ( S,R )-sulfoximine (50 mg/ml)) was provided by the National Cancer Institute (Bethesda, MD, USA)