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But consistently eating very low calories, especially around 500800 calories per day, can increase the risk of fatigue, weakness, muscle loss, hair shedding, constipation, and feeling awful

Rotate injection sites as recommended in the patient information leaflet, and if you notice any persistent redness or irritation at an injection site, protect that area from direct sun exposure until it has fully healed

Z.et al (2024a)

And there may be some people previously unresponsive to existing therapies who would benefit from trying orforglipron instead

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