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Quercetin also inhibits protein disulfide isomerase (PDI) enzyme involved in platelet-mediated thrombin formation, thus could ameliorate coagulation abnormalities in PASC 625

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A more detailed discussion of safety and tolerability are provided later

[4] [5] However, these studies predominantly involved populations with pre-diabetes or metabolic syndrome, and results may not generalise to individuals seeking weight loss without metabolic dysfunction

It would also be pertinent to add laboratory assays that allow putting the results in the larger context of cellular senescence, which seems to be disturbed in several disorders where fatigue has been associated with mitochondrial dysfunction