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tirzepatide targets GLP-1R and GIPR
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When it comes to this nutrient in particular, there are three things to pay attention to: #1
Mills EL, Ryan DG, Prag HA et al (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
DPP4 is also highly expressed in the liver and circulation in NAFLD and nonalcoholic steatohepatitis (NASH) patients [7, 8], and there is increasing evidence that DPP4 is highly involved in the development of chronic liver diseases [5, 9]
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