The GTP-binding protein RAB10 (RAB10) serves as a substrate for LRRK2, which may represent a pivotal link between PINK1/Parkin and LRRK2 (Wauters et al., 2020)
Cell Death Differ 28:28432856 Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ et al (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
This metabolic adaptability allows CSCs to resist standard chemotherapy and radiation, which often target rapidly proliferating, glycolysis-dependent tumor cells
The exopolysaccharide EPS forms fibrils that are necessary for S-motility 80 , while the spore coat polysaccharide CPS is the main component of the carbohydrate coat of fruiting body spores 83
Today, we know it is far more complex, shaped not only by diet and lifestyle but also by genetics