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Additionally, Atg5 knockout affects steroid hormone synthesis due to cholesterol deficiency caused by impaired autophagy (Texada et al., 2019)

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Even after quitting GLP-1 treatments, however, youre still getting at least some benefit [with at least 5 percent weight loss], which is great, says Chika Anekwe, an obesity medicine physician at Massachusetts General Hospital Weight Center, but not the entire benefit that you would if you could keep off the majority of the weight. Other studies paint a similar picture