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A total of 3183 patients with type 2 diabetes at high cardiovascular risk (age of 50 years with established cardiovascular and/or chronic kidney disease, or aged 60 years with cardiovascular risk factors only) were randomized to double-blind treatment with oral semaglutide or placebo added on to standard of care

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Again, similar to the results observed in mouse caSMCs, GLP-1(2836) activated PKA and conferred cytoprotection against oxidative stress injury in human caSMCs (Supplemental Figure 8, A and B)

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