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Although some exendin-4-based probes for SPECT and PET imaging showed their utilities in prospective clinical studies 13,14,15,16,17 , exendin-4-based probes with various chemical modifications are still being investigated for further improvement 13,18,19

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Patients should maintain consistency in their injection technique and rotate injection sites primarily to reduce the risk of injection site reactions

These results parallel a recent study of GCG missense mutations found in human populations (91), where fewer missense mutations were found at sites corresponding to the glucagon, GLP-1 and GLP-2 peptides