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The GRAS designation has created regulatory ambiguity: while AOD-9604 supplements are legally available, their marketing often implies therapeutic benefits that remain unproven

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In the latter case it is an autoimmune disease

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Previous studies have found that berberine inhibits cell death induced by 6-OHDA, and increases the expression of HO-1, ultimately protecting dopaminergic neurons (Shin et al., 2013)