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Ocular Very common (10% or more): Diabetic retinopathy (up to 20.1%) Common (1% to 10%): Retinal disorders, diabetic retinopathy complications Uncommon (0.1% to 1%): Nonproliferative retinopathy Very rare (less than 0.01%): Nonarteritic anterior ischemic optic neuropathy (NAION) Diabetic retinopathy complications included need for retinal photocoagulation, need for treatment with intravitreal agents, vitreous hemorrhage, and onset of diabetes-related blindness

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3.3.2 Nrf2 activators The activation of Nrf2-ARE signaling pathway also plays an important role in protecting against mitochondrial dysfunction through promoting mitophagy (Ran et al., 2022)

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