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Pediatric trials are quietly underway to support prescribing GLP-1 medications for obesity in children younger than 12, despite concerns about their long-term effects on developing bodies

The SELECT trial is a major breakthrough, says Yale Medicine cardiologist Harlan Krumholz, MD, SM, explaining that while semaglutide [given as Ozempic] was already known to lower the risk of heart disease in people with diabetes, the SELECT trial was the first to show that Wegovy, which contains a higher dose of semaglutide, also lowers that risk even in people who dont have diabetes

Semaglutide converts white adipose tissues into brown adipose tissues, a phenomenon called adipose tissue browning, and reduces dysfunctional adiposity in obesity

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Mean increases in resting heart rate have been observed in randomized clinical trials of semaglutide and are documented in FDA prescribing information