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In a nondiabetic glomerular injury model, alogliptin (20 mg/kg/day), anagliptin (300 mg/kg/day), or exendin-4 (10 mg/kg) significantly reduced infiltration of CD68-positive inflammatory macrophages in the kidney [107]

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Also watch for symptoms of gallbladder disease (right upper quadrant pain, fever, jaundice), which has been associated with GLP-1 medications and weight loss

The diverse demographics in these cohorts provide a robust foundation for comparing the agents outside of strictly controlled clinical environments