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High-carbohydrate midday options: as studies often use twice-a-day loading, it may be that some days both doses are with meals, whilst other days, one is with a meal and another is with carb drink after training

Studies have shown that JAK2 may also phosphorylate insulin receptor substrate 1/2 (IRS1/2) and activate the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway (Ridderstrale et al., 1995

In other words, a hypothetical unmeasured confounder could substantially bias our results only if it was both highly imbalanced between the exposure groups and strongly associated with the outcome

2014 Jun;53:30-7