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Previous studies have estimated that the economic burden of sarcopenia in the United States accounts for approximately 1.5% of total national health expenditures [7], with annual per capita healthcare costs rising by $2,315.7 in individuals with sarcopenia [8]

A January 2026 systematic review in Frontiers in Pharmacology from the Mayo Clinic confirmed the breadth of this signal across alcohol, nicotine, cocaine, and opioid models, both preclinical and clinical

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All supplementation dosages and administration routes will be considered, including gavage, intraperitoneal, orogastric or oral, simulating the natural route of the diet