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In addition to disturbances in mitochondrial pyruvate metabolism in diabetes, which contributes to excess hepatic gluconeogenesis, this disorder, as well as insulin resistance, is associated with disruptions in lipid and amino acid metabolic homeostasis

2019;181:R211R234

It also helps in the regeneration of glutathione, an enzyme that rids the body of free radicals

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If your medication has a warning not to eat grapefruit while taking it, you shouldnt take berberine with it, either.55 (Note, also, that berberine isnt the only supplement that interacts with cytochrome P450)