As the inflammatory response progresses, a glial scar is formed around the injury, consisting mostly of proteoglycans and reactive astrocytes
"We think that, by modulating cerebrospinal fluid pressure and reducing intracranial venous sinuses compression, these drugs produce a decrease in the release of calcitonin gene-related peptide (CGRP), a key migraine-promoting peptide", Dr Braca explained
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Methods 28 MannR.NasrN.HaddenD.SinfieldJ.AbidiF.Al-SabahS.et al (2007)