Introduction Thyroid oncocytic tumors (also called eosinophilic or oxyphilic tumors) are characterized by large polygonal cells with eosinophilic cytoplasm ( Although it has previously been reported that mitochondrial accumulation is due to compensated increase in mitochondrial biogenesis ( Recently, another mitochondrial quality control system has been found, in which mitochondriaeating protein (MIEAP) plays an indispensable role (called noncanonical mitophagy) ( Apc Min/+ ,Mieap KO/KO mice show more aggressive intestinal lesions than Apc Min/+ mice ( We have recently found that MIEAP was expressed in human thyroid nononcocytic (conventional) follicular adenomas (FAs), but not in oncocytic FAs and conventional and oncocytic carcinomas ( To further explore the roles of MIEAP in the oncocytic phenotype of thyroid tumors and in the carcinogenesis of thyroid cancers in general (that is, both oncocytic and conventional cancers) as a tumor suppressor, we utilized a mouse model of BRAF V600E positive thyroid cancer that we have previously established
A meta-analysis of Parkinson's disease and exposure to pesticides
Fait V, Sela S, Ophir E, Kreutzer H, Shnaider O, Perri A, et al
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