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Endothelial cells Diabetes-induced endothelial cell damage plays an important role, which ultimately leads to abnormal structure and function of BBB [2]

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Systematic Review

Visceral adiposity contributes to chronic low-grade inflammation through macrophage activation, altered T-cell responses, and adipokine imbalance ( Beyond obesity, insulin resistance and hyperinsulinemia appear to play an active role in sustaining inflammatory arthritis rather than representing mere epiphenomena of chronic inflammation

Risks and safety considerations GLP-1 medications are not right for everyone