Hooked up to IV bags, half of which contained GLP-1 and the other half just saline, the men were then encouraged to eat from a buffet lunch until they were comfortably satisfied
Numerous practice guidelines recommend multicomponent, evidence-based nutritional and behavioral therapy for adults with obesity, but use of such therapies with GLP-1s is not widespread
In June 2021, the FDA approved a higher-dose formulation of semaglutidemarketed under the brand name Wegovyspecifically for chronic weight management in adults with obesity or those who are overweight and have at least one weight-related health condition, such as type 2 diabetes, high blood pressure, or high cholesterol
It's important to note that weight loss itself is an evidence-based therapy for GERD, so the weight reduction achieved with these medications may actually improve reflux symptoms in some patients, potentially offsetting any direct effects on the gastroesophageal junction
At the same time, the visible nature of weight loss can reinforce adherence, at least in the early stages