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When levels are low, inflammation can become chronic and systemic, contributing to numerous health challenges

2018 Sep;110(4):570-577

Some patients stabilize at lower doses

Generally, if the receptors are ligand-gated ion channels, a conformational change opens the ion channels, which leads to a flow of ions across the cell membrane resulting in either a depolarization, for an excitatory receptor response, or a hyperpolarization, for an inhibitory response [277]