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Heparanase mediates renal dysfunction during early sepsis in mice

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Symptoms of acute kidney failure may include: Decreased urine output Swelling in legs, ankles, and feet Fatigue and drowsiness Shortness of breath Itching and joint pain Loss of appetite and nausea Confusion and seizures (in severe cases) Acute kidney failure can be caused by factors that affect blood flow to the kidneys, block urine from leaving the kidneys, or directly damage the kidneys

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