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Bbs5 / mice were characterized by hyperphagia, learning deficits, glucose/insulin intolerance, and disrupted metabolic hormones, phenocopying human BBS

The ongoing CONFIDENCE trial (NCT05254002) is an international randomised controlled double-blind trial that will directly assess the effects of finerenone plus empagliflozin on albuminuria and characterise the efficacy and safety of this drug combination in the setting of type 2 diabetes

With consistent lifestyle changes, improvements can begin within a few weeks, but significant metabolic restoration may take a few months depending on the individual.

According to a recent report, Ozempic and other weight loss drugs, including Wegovy, have been linked to 162 deaths in the U.S

Zheng et al., 2016