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Trials reported onset over roughly 4 to 8 weeks rather than immediately, with semaglutide averaging 15 to 22 percent of baseline body weight at the 2.4 mg maintenance dose and tirzepatide averaging 20 to 25 percent as a dual GLP-1 and GIP agonist

Our study revealed a hub gene, GADD45A , and its epigenetic regulation of ion channels (GADD45A/TET1-KCNQ5 axis), which plays a critical role in the pathogenesis of autism