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It is worth noting that the secretion of PYY and GLP-1 increased significantly after meals after Roux-en-Y gastric bypass surgery (RYGB), which is considered to be one of the key mechanisms for metabolic improvement brought about by the operation (152, 153)

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Tirzepatide May Activate Calorie-Burning Brown Fat in Obesity, Trial Suggests Key Takeaways: Findings from the TABFAT trial, presented at ENDO 2026, indicate that tirzepatide does more than curb appetite it also appears to activate brown adipose tissue, a heat-producing fat that burns calories

Gke Y, Danisman B, Akcay G, Derin N, Yara N (2023) l-Carnitine improves mechanical responses of cardiomyocytes and restores Ca2 + homeostasis during aging

Nausea occurs most frequently during dose initiation and escalation phases