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2001, AOD-9604 lost most of this fat-metabolism effect in mice that were genetically missing the beta-3 adrenergic receptor, suggesting that pathway carries part of the signal

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This makes injectable supplementation a reasonable approach for anyone with confirmed or suspected absorption problems, though it does not prove the combination provides benefits beyond separate administration

1 2 "Overview on Dietary Reference Values for the EU population as derived by the EFSA Panel on Dietetic Products, Nutrition and Allergies" (PDF)