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Previous study provided evidence for the presence of GLP-1 receptor in adipose tissue and show that its mRNA and protein expressions increased in visceral adipose depots from morbidly obese patients with a high degree of Insulin resistances (IR) ( It is well established that GLP-1/GLP-1R functions through activation of down-stream PKA-, MAPK-, or AMPK-related signaling pathways in various cells

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438 Among the numerous ERK1/2 target proteins, nucleation-promoting factors (NPFs) are thought to be mainly involved in neutrophil chemotaxis

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Une tude a montr quune anne aprs la fin du traitement, les patients avaient repris les deux tiers du poids initialement perdu