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Ganoderma lucidum is widely used in the treatment of bronchitis, gastric ulcer, hepatopathy, asthma, insomnia, chronic hepatitis, nephritis, arthritis and hypertension, weakness, fatigue, and cough (Halpern and Miller, 2002)

Among the four, three new interfacial salt bridges (Figures 3 and 4) were found to be formed due to the missense mutations introduced into semaglutides backbone (including in particular L23B R), whereas only one interfacial salt bridge (yellow row in Table 4) was found to be formed and the same as the salt bridge (Table 1) identified in PDB entry 4ZGM [24, 35]

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Currently, multiple signals and steps including NADPH-mediated ROS production, activation of kinase signaling cascades, and the release and translocation of granular enzymes have been demonstrated to initiate netotic cell death [186, 188] (Fig

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