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The retarded leaching of nanoclusters can be attributed to their large size in comparison with molecular dyes and it is a clear advantage for imaging purposes as dye leaching decreases the fluorescence brightness of NPs and increases the background signal resulting in unfavorable imaging inefficiency/artifacts 50

When elevated levels are identified, systematic investigation is required to determine the underlying cause

Mass production is challenging, repeatability is weak, and this novel medicine may cost more than more conventional ones

Put another way, chronic systemic inflammation keeps reinjuring what the other peptides are trying to rebuild