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Destruction of oxidatively-damaged RBCs is accomplished extravascularly by macrophages in the reticuloendothelial system 56

10.1016/j.brainres.2009.02.075 64 LindblomJ.OpmaneB.MutulisF.MutuleI.PetrovskaR.KlusaV.et al

Disulfide bonds are relatively stable under physiological conditions but undergo selective cleavage in the tumor microenvironment (TME), minimizing premature drug release [53]

With further optimization to the formulation and dosing of antioxidant gel-forming eye drops, there is potential for a topical therapy to protect photoreceptor function and survival for the treatment of RP