oasis-4 semaglutide Oral and the Future of GLP-1 Obesity Treatment, With Timothy Garvey, MD ECO 2026 - Early Responders

Abstract Amylin, a member of the calcitonin family, acts via amylin receptors in the hindbrain and hypothalamus to suppress appetite

Some individuals may experience: These effects are typically mild and temporary

Zepbound is a once-weekly subcutaneous injection in the stomach, thigh, or back of the upper arm

A 2023 retrospective cohort study published in Diabetes Care found that approximately 20% of patients initiated on a GLP-1 RA switched agents within the first 12 months, with GI intolerance and cost as the two most commonly documented reasons [7]

The current oral formulation of semaglutide requires higher dosing for significant weight loss