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Nonpyrogenic: Free from pyrogens, which are fever-inducing substances that can cause adverse reactions if injected

More recently, a longitudinal study among 3,849 community-living older adults in Ireland found that low vitamin B 12 serum concentrations ( 258-601 pmol/L) (101)

Significant main effects of treatment group (prior to BenjaminiHochberg correction since none were significant after correction, although the necessity of correction for multiple comparisons in exploratory analyses remains unresolved 49 ) were observed for the unclassified group and ten classified genera, namely, Acetatifactor , Akkermansia , Erysipelatoclostridium , [ Eubacterium ] coprostanoligenes group , Family XIII UCG-001 , Lactobacillus , Parasutterella , Ruminiclostridium 6 , Ruminococcaceae UCG-004 , and Ruminococcaceae UCG-009

A small human pilot study conducted showed no side effects

Are B-12 shots safe